With the rapid development of medicine, the variety of clinical drugs is increasing day by day. In the course of treating diseases, the number of adverse drug reactions (ADR) is also increasing year by year. In the various adverse reactions caused by drugs, gastrointestinal reactions occupy a considerable proportion, it is reported that in the monitoring of adverse reactions, gastrointestinal adverse reactions account for about 20% to 40%. The gastrointestinal tract (GI) is the body's largest digestive organ and the body's largest detoxification organ. Gastrointestinal adverse reactions caused by drugs can involve all parts of the digestive system, leading to digestive motor dysfunction, affecting the digestion and absorption of nutrients, and in severe cases, endangering the life of patients. The Gastrointestinal Toxic Drugs Database is a powerful tool for the study of gastrointestinal drug toxicity and related drug toxicology, containing 1023 compounds that can cause gastrointestinal adverse reactions, including non-steroidal anti-inflammatory drugs, anti-tumor drugs, antibiotics, drugs for the treatment of psychiatric disorders, etc. This database systematically collects the chemical structure, CAS number, pharmacological action type, clinical indications and possible adverse effects of various drugs, and describes the mechanism of gastrointestinal damage of drugs. To a certain extent, the database can provide relevant staff with data resources of gastrointestinal toxic drugs, understand and develop the relevant mechanisms of gastrointestinal adverse reactions, reduce the occurrence of gastrointestinal adverse reactions caused by drugs, and improve the quality of medical treatment.
