Specific biomarker database system for single-cell populations of colorectal cancer（SB-CRC）
Project
name：Specific biomarker database system for single-cell populations of colorectal cancer（SB-CRC）
BuildTime：2025-01-20
Mark
Colorectal cancer (CRC) is the most common malignant tumor of the digestive system, and its tumor cell-based treatment methods still face numerous challenges such as tumor metastasis, recurrence, and drug resistance, which urgently require further research. In the tumor microenvironment, the intricate interactions between tumor cells and immune cells significantly affect the progression of disease, and single-cell RNA sequencing is a powerful technique for exploring the complexity of the tumor microenvironment. Therefore, to explore the cell population status of the tumor microenvironment, in-depth exploration of specific biomarkers for single-cell population is a key research area in biomedical science. Based on literature research and information extraction analysis, a specific biomarker database system for single-cell populations of colorectal cancer (SB-CRC) was established to form a knowledge system for colorectal cancer cell research. To date, the database has collected 259 biomarkers, covering various aspects from tumor cells, immune cells to stromal cells, epithelial cells, fibroblasts, endothelial cells, myeloid cells, macrophages, monocytes, T cells, B cells, and dendritic cells. In addition, this database includes a comprehensive range of information entries, such as cell type, subcellular type, marker, Ensembl ID, category, description, related diseases, related pathways, Gene Ontology (GO) functional enrichment analysis, paralogue genes, reference databases, and pertinent literature references. This is significant for enhancing the accuracy of disease diagnosis, realizing personalized treatments, uncovering the mechanisms of disease onset, and promoting the development of new drugs, thereby providing new perspectives and tools for the advancement of biomedicine.
