Fecal-Specific Mutational Database of Fusobacterium nucleatum in Colorectal Cancer(CfFSNV)
Project
name：Fecal-Specific Mutational Database of Fusobacterium nucleatum in Colorectal Cancer(CfFSNV)
BuildTime：2026-02-22
Mark
Fusobacterium nucleatum (Fn) is a Gram-negative anaerobic bacterium that has been most extensively studied in the development and progression of colorectal cancer (CRC). Although Fn is typically found in the oral cavity, it is also specifically enriched in the feces and tumor tissues of CRC patients. As a common oral colonizer, Fn can translocate to the gut when the oral-gut barrier is compromised. It promotes the occurrence and progression of CRC through various mechanisms, rewrites the tumor microenvironment, and facilitates metastasis and chemotherapy resistance. Current microbiome research in CRC primarily focuses on taxonomic composition and microbial functional capacities, often overlooking extensive microbial genomic variation. Such genomic variations, including structural variants, insertions and deletions, as well as single nucleotide variants, represent an important yet underexplored dimension of microbial genetic diversity. These genetic alterations not only hold potential as differentiating biomarkers in samples but may also significantly impact microbial functions, including metabolic capabilities and interactions with the host. This database systematically analyzes Fusobacterium nucleatum-specific single nucleotide variants in CRC patients, laying a foundation for early diagnosis and targeted therapy.
