Cancer is a major health problem worldwide and has become the leading cause of death in China. In recent years, most of the anticancer drugs approved by FDA are natural products or derivatives of natural products. Alkaloids in natural products have the characteristics of high efficiency and low toxicity in antitumor. Based on the current research progress of natural plant alkaloids and their antitumor activity, alkaloids as the main antitumor active substances have broad development and research prospects. The application of alkaloid anticancer drugs will reduce the toxic and side effects of chemotherapeutic drugs and improve the efficacy of antitumor activity. In order to help the preliminary screening of alkaloids of compounds with antitumor activity for future study, this database from the viewpoint of cell biology and organic chemistry, analyzed the related literature information extraction, integration of data and a lot of research results, on the basis of building the database of alkaloids with antitumor activity (DAAA). This database contains the name, structure, molecular weight, molecular formula, activity, toxicity, patents and corresponding references of alkaloids. DAAA supports multiple query functions, such as “molecular weight”, “smiles”, etc. Therefore, this database will be used to help develop clinical alkaloids with antitumor activity.
