Database of Tumor Screening Based on Microbiome (DTS-MB)
Name：Database of Tumor Screening Based on Microbiome (DTS-MB)
Colorectal cancer (CRC) is a common clinical malignancy globally ranked as the fourth leading cause of cancer mortality. Some microbes are known to contribute to adenoma-carcinoma transition and possess diagnostic potential. Advances in high-throughput sequencing technology and functional studies have provided significant insights into the landscape of the gut microbiome and the fundamental roles of its components in carcinogenesis. With the aim of integrating the available data resources and facilitating comparative research, literature review and information extraction were performed, including microbe name, sensitivity, specificity, change of abundance, function of the microbe, technology, algorithm, number of cases, sources and links. Microbes that displayed statistical significance in both high-throughput sequencing/pyrosequencing and qPCR experiments were defined as 'Class One', those confirmed with one of the above techniques as 'Class Two', and combinations of different microbes for diagnosis as 'Class Three'. The interface supports query functions, such as “scientific name of the bacterium” and “taxonomy”. Thus, this knowledgebase will contribute to further study about CRC-related microbes and promotion of cost-effective and noninvasive CRC screening strategies.