PROTACs are a promising direction for new drug research, and have already been laid out by various pharmaceutical companies and related research institutes. All PROTACs are divided into peptide PROTACs and small molecule PROTACs, and each PROTAC is divided into three parts: targeting warheads for target proteins, linkers, and various ligands for ubiquitination. We summarized all the identified Linkers, ubiquitinated ligands and targeting warheads for different protein targets and labeled the target proteins with PDB numbers for PROTACs with protein and molecular structures. All of the above molecular structures are represented in SMILE format for a more intuitive understanding of the structures. We also provide the DOI number of each PROTAC molecular source article for a more direct understanding. This database is intended to be useful for basic research on PROTAC, such as the structures of different linkers and ubiquitinated ligands, and for related studies.
