Evodia rutaecarpa alkaloids are natural alkaloids extracted from Evodia rutaecarpa. It is reported that this biologically active alkaloid has a wide range of biological activities, including anti-injury, anti obesity, vasodilation, and anti-inflammatory effects. In recent years, it has been found that evodia rutaecarpa alkaloids have antitumor effects on a variety of tumors. There is increasing evidence that evodia rutaecarpa alkaloids can inhibit the rapid proliferation of tumor cells, induce cell cycle arrest at a certain stage, increase the incidence of apoptosis, promote autophagy, inhibit angiogenesis and migration, and regulate immunotherapy. In order to facilitate the query of the inhibitory effect and mechanism of evodia rutaecarpa alkaloids on common tumor cell lines, and facilitate the subsequent structural modification, with a view to finding evodia rutaecarpa alkaloids with significant tumor inhibitory effects, an anti-tumor database based on a large number of literature reviews was constructed. The database contains numerous entries such as the name, structure, molecular formula, molecular weight, anti-tumor cell line, IC50, action targets, clinical stages, and corresponding links of Evodia rutaecarpa alkaloids. Cancer is a major disease threatening human health. Currently, the main anticancer drugs include antimetabolites, alkylating agents, anti-tumor antibiotics, and anti-tumor botanical drugs, such as fluorouracil, nitrogen mustard, actinomycins, and vincristine. However, the research and development of new anticancer drugs has a long way to go. As a traditional Chinese medicine, some of the alkaloids of Evodia rutaecarpa can play an anti-tumor role well. Therefore, The database will be helpful for early screening of anti tumor drugs and make certain contributions to drug research and development.